Other side effects not listed may also occur in some patients. This medicine may cause loss or thinning of the scalp hair in some people. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy). This effect will continue for as long as the medicine is taken. Unexpected or excess milk flow from the breastsĪlso, many women who are taking estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding, similar to menstrual periods, again. Twitching, uncontrolled movements of the tongue, lips, face, arms, or legs Patchy brown or dark brown discoloration of the skin Large amount of triglyceride in the blood Unusual increase in sexual desire (in females)ĭull ache or feeling of pressure or heaviness in the legs Unusual decrease in sexual desire (in males) Painful cold sores or blisters on the lips, nose, eyes, or genitals Lower abdominal or stomach pain or pressure Increased hair growth, especially on the face Thick, white vaginal discharge with no odor or with a mild odorīurning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings Skin irritation or redness where skin patch was worn Redness of the face, neck, arms, and occasionally, upper chest Pain or tenderness around the eyes and cheekbones Itching of the vaginal, rectal or genital areas Increased clear or white vaginal discharge Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More commonĪbnormal growth filled with fluid or semisolid materialĮxcess air or gas in the stomach or intestines Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects may occur that usually do not need medical attention. Swelling of the abdominal or stomach area Sudden onset of shortness of breath for no apparent reason Sores, ulcers, or white spots in the mouth or on the lips Sore on the skin of the breast that does not heal Prominent superficial veins over affected area Partial or complete loss of vision in the eye Pains in the chest, groin, or legs, especially calves of the legs Painful, red lumps under the skin, mostly on the legs Pain, tenderness, swelling of the foot or leg Pain or feeling of pressure in the pelvis Pain or discomfort in the arms, jaw, back or neck Numbness or tingling of the hands, feet, or face Muscle spasm or jerking of all extremities Muscle cramps in the hands, arms, feet, legs, or face Inability to move the arms, legs, or facial muscles Shortness of breath (sudden and unexplained)īlistering, peeling, or loosening of the skinįull or bloated feeling or pressure in the stomach Pains in the chest, groin, or leg, especially in the calf of leg Loss of vision or change of vision (sudden) Lumps in, or discharge from, breast (in females and males) Swelling of the eyelids, face, lips, hands, or feetĬhanges in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding) Increased breast size (in females and males) These side effects occur rarely, and, when they do occur, they occur in men treated for cancer using high doses of estrogens.Ĭheck with your doctor immediately if any of the following side effects occur: More common The following side effects may be caused by blood clots, which could lead to stroke, heart attack, or death. Although not all of these side effects may occur, if they do occur they may need medical attention. Breast cancer has been reported in men taking estrogens.Īlong with its needed effects, a medicine may cause some unwanted effects. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.Īlthough the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. When estrogens are used in low doses for less than 1 year, there is less risk. This risk seems to increase as the dose and the length of use increase. The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause.
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